Whether you shoot JPEG or RAW, noise is best managed after capture. In-camera noise reduction will turn your sharp (albeit noisy) photos into impressionist paintings that lack fine detail. Turning all in-camera noise reduction off will solve half of the problem.  The solution lies in third party software noise reduction like Picture Code’s Noise Ninja. The software is available as a standalone program or as a plugin that can be integrated into your photoshop workflow. Noise Ninja is easy to use, cheap, and most importantly, it preserves fine detail.